As a Principal investigator of Shool of life sciences, Chongqing Univesrsity since July, 2018.
Research interests
We are interested in the host's immune response and the object's immune escape mechanism during the invasion of bacteria (Mycobacterium tuberculosis) or virus (SARS-COV-2).
Courses
Cell biology
Academic position
Serve as reviewer for some peer-reviewed journals, such as Nature communications, Ageing Research Reviews and Cellular and Molecular Life Sciences.
Major achievement
Selected Papers (#First author;*Corresponding author)
1. Wu H#, Xing N#, Meng K#, Fu B#, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X*, Meng G*, Zhu Z*, Nucleocapsid Mutations R203K/G204R Increase the Infectivity, Fitness and Virulence of SARS-CoV-2. Cell Host & Microbe. 2021;29(12):1788-1801.e6
2. Wu H, Wang Y, Zhang Y, Yang M, Lv J, Liu J, and Zhang Y. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci USA. 2015, Mar 31; 112(13): E1530–E1539. (Featured article, highlighted by Christopher K. Tuggle, PNAS, 2015)
3. Gao Y#, Wu H#, Wang Y#, Liu X, Chen L, Li Q, Cui C, Liu X, Zhang J, Zhang Y. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biology. 2017,18(1): 13.
4. Fu B#, Lin X#, Tan S#, Zhang R, Xue W, Zhang H, Zhang S, Zhao Q, Wang Y, Feldman K, Shi L, Zhang S, Nian W, Pavani K, Li Z*, Wang X*, Wu H*. MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death. EMBO Rep. 2021 Sep 6;22(9):e52252.
5. Fu B#, Xue W#, Zhang H#, Zhang R, Feldman K, Zhao Q, Zhang S, Shi L, Pavani KC, Nian W, Lin X*, Wu H*. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. mBio. 2020, 11:e00557-20.
6. Lin X#, Fu B#, Yin S#, Li Z, Liu H, Zhang H, Xing N, Wang Y, Xue W, Xiong Y, Zhang S, Zhao Q, Xu S, Zhang J, Wang P, Nian W*, Wang X*, Wu H*. ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293.
Awards
Chongqing Talents: Exceptional Young Talents Project (2020); Young Talent Fund of University Association for Science and Technology in Shaanxi, China (2017); Excellent Doctoral Dissertation of Shaanxi Province(2017).
Postgraduate training
There are 2 postdoctoral fellows, 3 doctoral candidates and 5 master candidates in the research group.
Contact information
Email: hbwu023{at}cqu.edu.cn